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pentobarbital will lower the extent or effect of parecoxib by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Keep track of.Contraindicated (one)pentobarbital will minimize the extent or effect of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is responsible for the formation and eliminati